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Characterization of the adsorption process analogouspeptides on alumina gel

Trujillo, Mary and Salazar, Luz Mary and Valencia, Jesus (2011) Characterization of the adsorption process analogouspeptides on alumina gel. Revista Colombiana de Química; Vol. 40, núm. 3 (2011); 391-399 0120-2804 .

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Peptide antigen adsorption on aluminumhydroxide gel must be characterizedwhen formulating vaccines. In this worka peptide belonging to the amino-terminalregion of Plasmodium falciparum MerozoiteSurface Protein and its analogueshave been characterized. The adsorptionof 17 analogues on aluminum hydroxidewhich had greater than 10 mmol/L solubilitywas quantified at 298 K. Adsorptioncapacity and affinity constant parameterswere calculated by applying theLangmuir's adsorption model.The results have been presented inthree groups according to adsorption isothermtrajectory. The first group consistsof analogues where the first organizationof peptide molecules was presented atlow concentrations, followed by a rapidincrease in adsorption to high concentrations.The second group consists ofanalogues having an adsorption patternshowing the formation of a first layer atlow peptide concentrations and a secondlayer at greater concentrations. The thirdgroup contains analogues whose adsorptioninvolved the formation of two simplelayers, this being differentiated fromthe second group in that after the secondlayer had been completed, the amountadsorbed grew notably with increasedconcentration.The results revealed a more complexpattern that monolayer or bilayer formation.This work constitutes the firstapproach towards establishing an adsorbedlayer structure model using a peptidesystem.

Tipo de documento:Artículo - Article
Unidad administrativa:Revistas electrónicas UN > Revista Colombiana de Química
Código ID:30587
Enviado por : Dirección Nacional de Bibliotecas STECNICO
Enviado el día :30 Junio 2014 12:20
Ultima modificación:18 Agosto 2014 19:07
Ultima modificación:18 Agosto 2014 19:07
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