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The cost-effectiveness of open or thoracoscopic thymectomy compared to medical treatment in managing myasthenia gravis without thymomas

Chicaiza Becerra, Liliana Alejandra and García Molina, Mario and Gamboa, Oscar and Castañeda, Carlos (2012) The cost-effectiveness of open or thoracoscopic thymectomy compared to medical treatment in managing myasthenia gravis without thymomas. Journal of Public Health; Vol. 14, núm. 2 (2012); 260-270 Revista de Salud Pública; Vol. 14, núm. 2 (2012); 260-270 0124-0064 .

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Resumen

Objective Assessing the cost-effectiveness of open or thoracoscopic thymectomycompared to medical therapy in managing myasthenia gravis not associated with thymoma.Methods A Markov model was designed for evaluating three strategies’ costeffectiveness.Transition probabilities were taken from the pertinent literature; the costs were estimated from official tariff manuals. Incremental cost-effectiveness ratios were estimated and probabilistic and deterministic sensitivity analysis was used for clinical variables, costs and the model´s assumptions.Results Thoracoscopic thymectomy was the most effective and least costly strategy and dominated the other two alternatives. The cost per life year gained was Col $ 1 129 531 without discount and Col $ 805 179 with discount. Univariate sensitivity analysis showed that the main variables affecting the results were the effects’ discount rate, the cost of a myasthenic crisis and the probability of complete remission. Thoracoscopy thymectomy was the most cost-effective strategy for different thresholds of willingness to pay in probabilistic analysis.Conclusions Thoracoscopic thymectomy is a cost-effective strategy in the treatment of MG without thymoma.

Tipo de documento:Artículo - Article
Palabras clave:Medicina, economía, economía de la salud, Myasthenia gravis, therapeutics, thymectomy, cost-benefit analysis, Colombia.
Unidad administrativa:Revistas electrónicas UN > Revista de Salud Pública
Código ID:23799
Enviado por : Dirección Nacional de Bibliotecas STECNICO
Enviado el día :27 Junio 2014 15:03
Ultima modificación:18 Agosto 2014 16:31
Ultima modificación:18 Agosto 2014 16:31
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